Detailed view for LOAG_02238

Basic information

TDR Targets ID: 945769
Loa Loa (eye worm), hypothetical protein
Source Database / ID:  KEGG  

pI: 4.7773 | Length (AA): 1255 | MW (Da): 141491 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
GO:0031213   RSF complex  
GO:0006355   regulation of transcription, DNA-dependent  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
496 547 5vab (A) 19 70 46.00 0 0.99 0.418934 0.42
502 549 1f62 (A) 3 50 48.00 0.00000017 0.96 0.509947 0.95
505 547 5mr8 (A) 890 932 35.00 0.8 0.78 0.408963 0.44
911 974 5hzp (C) 63 126 5.00 0 0 0.137496 -1.76
1193 1235 1jvr (A) 91 133 33.00 0.035 0.02 0.215263 1.28

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_133938)

Species Accession Gene Product
Brugia malayi Bm1_54405   PHD-finger family protein
Drosophila melanogaster Dmel_CG8677   CG8677 gene product from transcript CG8677-RC
Echinococcus granulosus EgrG_001085700   remodeling and spacing factor 1
Echinococcus multilocularis EmuJ_001085700   remodeling and spacing factor 1
Homo sapiens ENSG00000048649   remodeling and spacing factor 1
Loa Loa (eye worm) LOAG_02238   hypothetical protein
Mus musculus ENSMUSG00000035623   remodeling and spacing factor 1
Onchocerca volvulus OVOC3177   Remodeling and spacing factor 1 homolog
Schistosoma japonicum Sjp_0023790   Remodeling and spacing factor 1, putative
Schistosoma mansoni Smp_094360   hepatitis B virus X associated protein hbxa
Schmidtea mediterranea mk4.041693.00   Remodeling and spacing factor 1
Schmidtea mediterranea mk4.009776.01   Putative hepatitis B virus X associated protein, hbxa
Schmidtea mediterranea mk4.005094.06   Putative hepatitis B virus X associated protein, hbxa

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier LOAG_02238 (Loa Loa (eye worm)), hypothetical protein
Title for this comment
Comment